A-Cyst##R##(Rx)

(GAG) layer bladder replenishment for cystitis and more

Category: Intravesical/Bladder

Active Ingredient(s): hyaluronic acid + chondroitin sulfates C4 & C6 + N-acetyl-D-glucosamine sterile solution

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What is A-CYST^®?

A-CYST^® is a patented formulation designed for temporary replenishment of the glycosaminoglycan (GAG) layer in the urinary bladder. A-CYST^® contains naturally occurring components of the GAG layer of bladder epithelium. The GAG layer normally provides a protective barrier against microorganisms, carcinogens, crystals and other agents present in urine. The GAG layer has been identified as a primary defense mechanism from these irritants. Deficiencies in the GAG layer may affect epithelial barrier function and allow adherence of bacteria, microcrystals, proteins and ions, or movement of solute residues (i.e., urea).

The GAG layer of the bladder is deficient in cystitis. GAG deficiency contributes to clinical symptoms in diseases such as feline idiopathic cystitis (FIC), feline lower urinary tract disease (FLUTD), and cystitis caused by infections, trauma, urolithiasis, urinary retention and neoplasia.

A-CYST^® has been designed for use in cystitis to temporarily coat and help replenish the deficient GAG layer on bladder epithelium.

Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Indications

Benefits

Reduced the overall 7-days repeat obstruction rate to 0%, versus a placebo group rate of 42% in a pilot study on intravesical infusion of A-CYST of blocked toms performed at the Colorado State University. ¹
Helps replenish GAGs of the bladder epithelium with naturally occurring elements.
Temporarily coats the bladder epithelium to help restore the barrier function.
Versatile: can be administered to both cats and dogs

¹ Bradley, AM, Lappin, MR. Intravesical glycosaminoglycans for obstructive feline idiopathic cystitis: a pilot study. Journal of Feline Medicine and Surgery 2014, Vol. 16(6) 504–506.